One of Jim Beloff's recent newsletters had a photo of William H. Macy stumming his uke. Here's an interview with Macy in which he talks about playing the uke. (Acutally, I've pasted the whole reference below, but if you're a WHM fan, it's a good interview.)
"Q: What are you listening to right now?Link Discuss
"Macy: Jim Beloft (sic). I’m crazed for ukulele. I started playing ukulele about four years ago, and matter of fact when we get home, on Monday night I’m doing a breast cancer benefit and I’m playing a song that Jim wrote and, oh God… Oh God, I still don’t know the words…"