Dave Means makes gorgeous custom ukes under the Glyph name. He adds all kinds of flourishes that connect the instrument to the owner. Of note, he's made a custom concert for Ben Thompson, a teacher and founder of the George Fox Middle School Ukulele Ensemble. Thompson has used the uke with his students to build awareness of the Chesapeake Bay sub-aquatic ecosystem. The fretboard on Ben's uke shows (among other critters) a blue crab hiding among endangered submerged aquatic grasses (celery grass and redhead grass).
Or how about this spruce-topped Mahogany "Double-Helix" concert that Dave built for microbiologist Paul Goodrich. Presumably, you'd tune it in both D and A. (Sorry.)